41 Games: Tales from Space: Mutant Blogs Attack
You are a blob. You absorb everything you touch. The more you absorb, the bigger you get. You start each new level small, and are enormous (relative to the scale of the level) by the end. But the trick is: the levels themselves are getting bigger each time. From dorm room snacks to entire cities ... what could have been a set of disconnected levels exploring a relatively simple mechanic becomes something delightfully mischievous.
I like to joke that many video games are just about tidying up. In that sense, Tales from Space: Mutant Blobs Attack is the ultimate video game.